In a significant moment for the University of Louisville football program, running back Isaac Guerendo was selected with the No. 129 pick in the fourth round of the 2024 NFL Draft by the San Francisco 49ers.
Guerendo’s selection marks a historic milestone, as he becomes Louisville’s 137th draft pick of all time and the 19th running back taken in school history. Hailing from Avon, Indiana, Guerendo joined Louisville after a distinguished collegiate career that began at Wisconsin.
During his time with the Cardinals, Guerendo made an immediate impact, emerging as the team’s second-leading rusher in the 2023 season. He amassed 810 yards and 11 touchdowns while averaging an impressive 6.1 yards per carry. Head coach Jeff Brohm commended Guerendo’s professionalism and dedication, emphasizing his positive influence both on and off the field.
Guerendo’s standout performances included two memorable 100-yard rushing games. In a pivotal matchup against Virginia, he showcased his explosiveness with 146 yards and three touchdowns, including a game-winning 73-yard dash to secure a crucial victory for Louisville. Despite a tough loss in the Holiday Bowl against USC, Guerendo delivered a stellar showing, tallying a season-high 161 yards and three touchdowns against the Trojans.
With Guerendo’s selection, the Cardinals continue to bolster their reputation as a talent pipeline for the NFL, boasting a total of 34 players drafted since 2010. Guerendo joins an elite group of Louisville alumni drafted by the San Francisco 49ers, becoming the seventh player in school history to don the iconic red and gold jersey.
As Guerendo embarks on his professional journey with the 49ers, Louisville fans eagerly anticipate watching him thrive at the next level. With his exceptional skills and unwavering determination, Guerendo is poised to make a lasting impact in the NFL, representing the Cardinals with pride and distinction.
